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ZDLD13

CAT: 0804-HY-115908Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-115908Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZDLD13, a β-carboline, is an orally active and selective CDK4/CycD3 inhibitor with an IC50 value of 0.38 μM. ZDLD13 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD13 shows significant tumor growth inhibition in HCT116 tumor xenograft model[1].
CAS Number
2762278-95-3
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zdld13.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC=CC2=C1NC3=C2C=CC=C3)NCC4=NC=CC=C4
Molecular Formula
C18H14N4O
Molecular Weight
302.33
References & Citations
[1]Deping Li, et al. Facile synthesis of C1-substituted β-carbolines as CDK4 inhibitors for the treatment of cancer. Bioorg Chem. 2022 Apr;121:105659.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4

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