MIF2-IN-1

• UNSPSC Description:

  MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases[1].

• Target Antigen:

  Macrophage migration inhibitory factor (MIF); Others

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mif2-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=C(C2=O)C(C)=C(C3=CC(C(F)(F)F)=CC=C3)S1)N2[C@H](C)C4=C5C(C=CC=C5)=CC=C4

• Molecular Weight:

  480.50

• References & Citations:

  [1]Xiao Z, et al. Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells. J Med Chem. 2022 Feb 10;65(3):2059-2077.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2917525-79-0