GW-3333

• Description :

  GW-3333 is a potent and orally active TNF-alpha-converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitor. GW-3333 inhibits tumor necrosis factor-alpha (TNF-alpha) production. GW-3333 can be used in research of arthritis[1][2].

• UNSPSC :

  12352005

• Target :

  MMP; TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/gw-3333.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC[C@@H]([C@H](NC([C@@H]([C@@H](N(O)C=O)C(C)C)CC(C)C)=O)C(NC1=CC=CC=N1)=O)C

• Molecular Formula :

  C22H36N4O4

• Molecular Weight :

  420.55

• References & Citations :

  [1]Conway JG, et, al. Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases. J Pharmacol Exp Ther. 2001 Sep;298 (3) :900-8.|[2]Doggrell SA. TACE inhibition: a new approach to treating inflammation. Expert Opin Investig Drugs. 2002 Jul;11 (7) :1003-6.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [212609-68-2]