GW-3333

CAT: 0804-HY-115351Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-115351Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GW-3333 is a potent and orally active TNF-alpha-converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitor. GW-3333 inhibits tumor necrosis factor-alpha (TNF-alpha) production. GW-3333 can be used in research of arthritis[1][2].
CAS Number
[212609-68-2]
UNSPSC
12352005
Target
MMP; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gw-3333.html
Solubility
10 mM in DMSO
Smiles
CC[C@@H]([C@H](NC([C@@H]([C@@H](N(O)C=O)C(C)C)CC(C)C)=O)C(NC1=CC=CC=N1)=O)C
Molecular Formula
C22H36N4O4
Molecular Weight
420.55
References & Citations
[1]Conway JG, et, al. Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases. J Pharmacol Exp Ther. 2001 Sep;298 (3) :900-8.|[2]Doggrell SA. TACE inhibition: a new approach to treating inflammation. Expert Opin Investig Drugs. 2002 Jul;11 (7) :1003-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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