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SB-747651A

CAT: 0804-HY-114038Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114038Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-747651A is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A can be used for inflammation research[1].
CAS Number
607372-46-3
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sb-747651a.html
Solubility
10 mM in DMSO
Smiles
NC1=NON=C1C(N2CC)=NC3=C2C(CNC4CCNCC4)=CN=C3
Molecular Formula
C16H22N8O
Molecular Weight
342.40
References & Citations
[1]Feiner B, et al. Risperidone effects on heterochromatin: the role of kinase signaling. Clin Exp Immunol. 2019;196 (1) :67-75.|[2]Hossain M, et al. The Specific Mitogen- and Stress-Activated Protein Kinase MSK1 Inhibitor SB-747651A Modulates Chemokine-Induced Neutrophil Recruitment. Int J Mol Sci. 2017;18 (10) :2163. Published 2017 Oct 17.|[3]Shaista Naqvi, et al. Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem J. 2012 Jan 1;441 (1) :347-57.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported