Lipoxin A4

CAT: 0804-HY-113509Size: 25 μg (283.71 μM x 250 μL in Ethanol)Dry Ice: YesHazardous: No
CAT#:0804-HY-113509Size:25 μg (283.71 μM x 250 μL in Ethanol)
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA) -mediated IL-8 release with an IC50 value of 25.74 nM[3].
CAS Number
[89663-86-5]
Product Name Alternative
LXA4
UNSPSC
12352211
Hazard Statement
H225, H319
Target
Endogenous Metabolite; Interleukin Related
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lipoxin-a4.html
Concentration
283.71 μM * 250 μL in Ethanol
Purity
98.00
Solubility
10 mM in DMSO
Smiles
CCCCC[C@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCCC(O)=O
Molecular Formula
C20H32O5
Molecular Weight
352.47
Precautions
H225, H319
References & Citations
[1]Feng Hu, et al. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes associated with the ERK1/2 and NF-κB pathways. J Dermatol Sci. 2015 Jun;78 (3) :181-8.|[2]Steven Bozinovski, et al. Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2012 Jan 17;109 (3) :935-40.|[3]Xinxin Liu, et al. Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis.Sci Rep. 2017 Aug 2;7 (1) :7100.|[4]Miao GS, et al. Lipoxin A4 attenuates radicular pain possibly by inhibiting spinal ERK, JNK and NF-κB/p65 and cytokine signals, but not p38, in a rat model of non-compressive lumbar disc herniation. Neuroscience. 2015 Aug 6;300:10-8.
Shipping Conditions
Dry Ice
Storage Conditions
Solution, -20°C, 1 year
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; IL-6; IL-8

Related Products

CatalogName
HY-115381Lipoxin A5
HY-116953Lipoxin B4
HY-134123Lipoxin B4 methyl ester
HY-N14467Pneumocandin A4
HY-N2146-01Combretastatin A4
HY-N4146-01Proanthocyanidin A4
HY-126906-01Milbemycin A4
HY-N13468Sibiricose A4
HY-N8440-01Gibberellin A4
HY-124129-0110074-A4

Alternative Products

CatalogName
453783-01Lipoxin A5
T36051Lipoxin A4
MBS5785205Lipoxin B4
MBS5782347Lipoxin C4
MBS762533-01Lipoxin A4 ELISA Kit
MBS57982376(S)-Lipoxin A4
OKEH02620-96WLipoxin B4 ELISA Kit

Popular Products