Milbemycin A4

• Description:

  Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity[1]sup>[2].

• UNSPSC:

  12352005

• Hazard Statement:

  H350

• Target:

  Antibiotic; P-glycoprotein

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/milbemycin-a4.html

• Purity:

  99.13

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1[C@]2 ([H]) C=C (C) [C@@H] (O) [C@]3 ([H]) [C@@]2 (O) /C (CO3) =C/C=C/[C@H] (C) C/C (C) =C/C[C@]4 ([H]) C[C@@] (O1) ([H]) C[C@@]5 (O[C@H] (CC) [C@@H] (C) CC5) O4

• Molecular Formula:

  C32H46O7

• Molecular Weight:

  542.70

• Precautions:

  H350

• References & Citations:

  [1]Li J, et al. Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60. J Antibiot (Tokyo) . 2017 Mar;70 (3) :297-300.|[2]Takiguchi Y, et al. Milbemycins, a new family of macrolide antibiotics: fermentation, isolation and physico-chemical properties. J Antibiot (Tokyo) . 1980 Oct;33 (10) :1120-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Macrolide

• CAS Number:

  51596-11-3