Milbemycin A4

• Description :

  Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity[1]sup>[2].

• UNSPSC :

  12352005

• Hazard Statement :

  H350

• Target :

  Antibiotic; P-glycoprotein

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/milbemycin-a4.html

• Purity :

  99.13

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1[C@]2([H])C=C(C)[C@@H](O)[C@]3([H])[C@@]2(O)/C(CO3)=C/C=C/[C@H](C)C/C(C)=C/C[C@]4([H])C[C@@](O1)([H])C[C@@]5(O[C@H](CC)[C@@H](C)CC5)O4

• Molecular Formula :

  C32H46O7

• Molecular Weight :

  542.70

• Precautions :

  H350

• References & Citations :

  [1]Li J, et al. Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60. J Antibiot (Tokyo) . 2017 Mar;70 (3) :297-300.|[2]Takiguchi Y, et al. Milbemycins, a new family of macrolide antibiotics: fermentation, isolation and physico-chemical properties. J Antibiot (Tokyo) . 1980 Oct;33 (10) :1120-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Macrolide

• CAS Number :

  [51596-11-3]