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Milbemycin A4

CAT: 0804-HY-126906-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-126906-01Size:1 mg
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Description
Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity[1]sup>[2].
CAS Number
[51596-11-3]
UNSPSC
12352005
Hazard Statement
H350
Target
Antibiotic; P-glycoprotein
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/milbemycin-a4.html
Purity
99.13
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1[C@]2([H])C=C(C)[C@@H](O)[C@]3([H])[C@@]2(O)/C(CO3)=C/C=C/[C@H](C)C/C(C)=C/C[C@]4([H])C[C@@](O1)([H])C[C@@]5(O[C@H](CC)[C@@H](C)CC5)O4
Molecular Formula
C32H46O7
Molecular Weight
542.70
Precautions
H350
References & Citations
[1]Li J, et al. Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60. J Antibiot (Tokyo) . 2017 Mar;70 (3) :297-300.|[2]Takiguchi Y, et al. Milbemycins, a new family of macrolide antibiotics: fermentation, isolation and physico-chemical properties. J Antibiot (Tokyo) . 1980 Oct;33 (10) :1120-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Macrolide

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