Uridine 5'-diphosphate-15N2 (dilithium)

• UNSPSC Description:

  Uridine 5'-diphosphate-15N2 dilithium is 15N labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.

• Target Antigen:

  Endogenous Metabolite; Isotope-Labeled Compounds; P2Y Receptor

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein;Metabolic Enzyme/Protease;Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/uridine-5-diphosphate-15n2-dilithium.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H]1[C@H](O)[C@@H](COP(OP(O[Li])(O[Li])=O)(O)=O)O[C@H]1[15N](C([15NH]2)=O)C=CC2=O

• Molecular Weight:

  418.01

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Ashleigh S Paparella, et al. Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State. ACS Chem Biol. 2022 Sep 16;17(9):2507-2518.|[3]Besada P, et al. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J Med Chem. 2006 Sep 7;49(18):5532-43.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported