Uridine 5'-diphosphate-13C9,15N2 (dilithium)

Uridine 5'-diphosphate-13C9,15N2 (dilithium)

• UNSPSC Description: Uridine 5'-diphosphate-13C9,15N2 dilithium is 13C and 15N-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds; P2Y Receptor
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease;Others
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/uridine-5-diphosphate-13c9-15n2-dilithium.html
• Purity: 99.5
• Solubility: 10 mM in DMSO
• Smiles: O[13C@@H]1[13C@H](O)[13C@@H]([13CH2]OP(OP(O[Li])(O[Li])=O)(O)=O)O[13C@H]1[15N]2[13C]([15NH][13C]([13CH]=[13CH]2)=O)=O
• Molecular Weight: 426.95
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Ashleigh S Paparella, et al. Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State. ACS Chem Biol. 2022 Sep 16;17(9):2507-2518.|[3]Besada P, et al. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J Med Chem. 2006 Sep 7;49(18):5532-43.
• Shipping Conditions: Blue Ice
• Storage Conditions: Solution, -20°C, 2 years
• Clinical Information: No Development Reported