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7-Methylguanine-d3

CAT: 0804-HY-113352SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113352SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7-Methylguanine-d3 is the deuterium labeled 7-Methylguanine[1]. 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method[2].
CAS Number
17829-03-7
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(N=CN2C([2H])([2H])[2H])NC(N)=N1
Molecular Formula
C6H4D3N5O
Molecular Weight
168.17
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130 (35) :11570-1.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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