DBCO-NHCO-PEG4-NHS ester
CAT:
804-HY-111456
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
DBCO-NHCO-PEG4-NHS ester
- CAS Number: 2100306-58-7
- UNSPSC Description: DBCO-NHCO-PEG4-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-NHCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- Target Antigen: ADC Linker; PROTAC Linkers
- Type: ADC Related
- Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/dbco-nhco-peg4-nhs-ester.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(CCC1=O)N1OC(CCOCCOCCOCCOCCC(NCCC(N2C3=CC=CC=C3C#CC4=CC=CC=C4C2)=O)=O)=O
- Molecular Weight: 649.69
- References & Citations: [1]Thornlow DN, et al. Dual Site-Specific Antibody Conjugates for Sequential and Orthogonal Cargo Release. Bioconjug Chem. 2019 Jun 19;30(6):1702-1710.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported