DBCO-NHCO-C4-NHS ester
CAT:
804-HY-133371
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
DBCO-NHCO-C4-NHS ester
- UNSPSC Description: DBCO-NHCO-C4-NHS ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NHCO-C4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- Target Antigen: PROTAC Linkers
- Type: Reference compound
- Related Pathways: PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/dbco-nhco-c4-nhs-ester.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCNC(CCCCC(ON4C(CCC4=O)=O)=O)=O
- Molecular Weight: 501.53
- References & Citations: [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported