PC DBCO-PEG4-NHS ester

PC DBCO-PEG4-NHS ester

• CAS Number: 2055025-02-8
• UNSPSC Description: PC DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PC DBCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: PROTAC Linkers
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pc-dbco-peg4-nhs-ester.html
• Solubility: 10 mM in DMSO
• Smiles: [O-][N+](C(C(C(OC(ON1C(CCC1=O)=O)=O)C)=C2)=CC(OCCCC(NCCOCCOCCOCCOCCC(NCCC(N3CC4=C(C=CC=C4)C#CC5=C3C=CC=C5)=O)=O)=O)=C2OC)=O
• Molecular Weight: 945.96
• References & Citations: [1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported