EBI-1051

• Description :

  EBI-1051 is a highly potent and orally efficacious MEK inhibitor with an IC50 of 3.9 nM.

• UNSPSC :

  12352005

• Target :

  MEK

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/EBI-1051.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NOC(CO)CO)C1=C(NC2=CC=C(I)C=C2F)C(F)=C3C(C=CO3)=C1

• Molecular Formula :

  C18H15F2IN2O5

• Molecular Weight :

  504.22

• References & Citations :

  [1]Lu B, et al. Discovery of EBI-1051: A novel and orally efficacious MEK inhibitor with benzofuran scaffold. Bioorg Med Chem. 2018 Feb 1;26 (3) :581-589.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1801896-05-8]