EBI-2511

• Description:

  EBI-2511 is a highly potent and orally active EZH2 inhibitor, with an IC50 of 6 nM in Pfeffiera cell lines, respectively.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/EBI-2511.html

• Purity:

  99.81

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  CCC1=C (C (NCC2=C (C) C=C (C) NC2=O) =O) C (C=C (C3CCN (C (C) C) CC3) O4) =C4C=C1N (C5CCOCC5) CC

• Molecular Formula:

  C34H48N4O4

• Molecular Weight:

  576.77

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Lu B, et al. Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma. ACS Med Chem Lett. 2018 Jan 29;9 (2) :98-102.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  EZH2

• CAS Number:

  2098546-05-3