DSP-1053

• Description:

  DSP-1053, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM. DSP-1053 shows partial 5-HT1A receptor agonistic activity with a Ki of 5.05 nM. DSP-1053 has antidepressant activity[1].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Serotonin Transporter

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/DSP-1053.html

• Purity:

  99.75

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  BrC1=CC=C (CC2CCN (CCC3=CC (C (CCO4) =O) =C4C=C3) CC2) C=C1OCCOC

• Molecular Formula:

  C26H32BrNO4

• Molecular Weight:

  502.44

• References & Citations:

  [1]Yoshinaga H, et al. Discovery of DSP-1053, a novel benzylpiperidine derivative with potent serotonin transporter inhibitory activity and partial 5-HT1A receptor agonistic activity. Bioorg Med Chem. 2018 May 1;26 (8) :1614-1627.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  5-HT1 Receptor; mLAG-3

• CAS Number:

  1176326-76-3