DSP-1053

• Description :

  DSP-1053, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM. DSP-1053 shows partial 5-HT1A receptor agonistic activity with a Ki of 5.05 nM. DSP-1053 has antidepressant activity[1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Serotonin Transporter

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/DSP-1053.html

• Purity :

  99.75

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  BrC1=CC=C(CC2CCN(CCC3=CC(C(CCO4)=O)=C4C=C3)CC2)C=C1OCCOC

• Molecular Formula :

  C26H32BrNO4

• Molecular Weight :

  502.44

• References & Citations :

  [1]Yoshinaga H, et al. Discovery of DSP-1053, a novel benzylpiperidine derivative with potent serotonin transporter inhibitory activity and partial 5-HT1A receptor agonistic activity. Bioorg Med Chem. 2018 May 1;26 (8) :1614-1627.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  5-HT1 Receptor; mLAG-3

• CAS Number :

  [1176326-76-3]