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AJ-76

CAT: 0804-HY-111283Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-111283Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AJ-76 ((+) -AJ 76; (1S,2R) -AJ 76) is a dopamine autoreceptor antagonist. AJ-76 can increase the synthesis and turnover of dopamine in the rat brain, while having little effect on the synthesis and turnover of serotonin (5-HT) and norepinephrine. AJ-76 can also antagonize the sedative effects of low-dose apomorphine and has a weak antagonistic effect on postsynaptic dopamine receptor[1].
CAS Number
[85379-09-5]
Product Name Alternative
(+) -AJ 76; (1S,2R) -AJ 76
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aj-76.html
Solubility
10 mM in DMSO
Smiles
CCCN[C@H]1[C@@H](C)C2=C(C(OC)=CC=C2)CC1
Molecular Formula
C15H23NO
Molecular Weight
233.35
References & Citations
[1]Svensson K, et al. (+) -AJ 76 and (+) -UH 232: central stimulants acting as preferential dopamine autoreceptor antagonists. Naunyn Schmiedebergs Arch Pharmacol. 1986 Nov;334 (3) :234-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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