AJ-76

• Description :

  AJ-76 ((+) -AJ 76; (1S,2R) -AJ 76) is a dopamine autoreceptor antagonist. AJ-76 can increase the synthesis and turnover of dopamine in the rat brain, while having little effect on the synthesis and turnover of serotonin (5-HT) and norepinephrine. AJ-76 can also antagonize the sedative effects of low-dose apomorphine and has a weak antagonistic effect on postsynaptic dopamine receptor[1].

• Product Name Alternative :

  (+) -AJ 76; (1S,2R) -AJ 76

• UNSPSC :

  12352005

• Target :

  Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/aj-76.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCN[C@H]1[C@@H](C)C2=C(C(OC)=CC=C2)CC1

• Molecular Formula :

  C15H23NO

• Molecular Weight :

  233.35

• References & Citations :

  [1]Svensson K, et al. (+) -AJ 76 and (+) -UH 232: central stimulants acting as preferential dopamine autoreceptor antagonists. Naunyn Schmiedebergs Arch Pharmacol. 1986 Nov;334 (3) :234-45.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [85379-09-5]