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A-425619

CAT: 0804-HY-110292-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110292-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-425619 is an orally active and selective transient receptor potential type V1 (TRPV1) antagonist. A-425619 blocks Capsaicin - and N-arachidonoyl-dopamine (NADA) -induced Ca2+ influx in dorsal root ganglia and trigeminal ganglia. A-425619 relieves pathophysiological pain associated with inflammation and tissue injury in rats. A-425619 can be used for the study of pain related to inflammation and tissue injury[1][2][3].
CAS Number
581809-67-8
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Calcium Channel; TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/a-425619.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)C(C=C1)=CC=C1CNC(NC2=CC=CC3=C2C=CN=C3)=O
Molecular Formula
C18H14F3N3O
Molecular Weight
345.32
Precautions
H315, H319, H320
References & Citations
[1]McDonald HA, et al. Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia. Eur J Pharmacol. 2008 Oct 31;596 (1-3) :62-9. |[2]El Kouhen R, et al. A-425619 [1-isoquinolin-5-yl-3- (4-trifluoromethyl-benzyl) -urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid. J Pharmacol Exp Ther. 2005 Jul;314 (1) :400-9. |[3]Honore P, et al. A-425619 [1-isoquinolin-5-yl-3- (4-trifluoromethyl-benzyl) -urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. J Pharmacol Exp Ther. 2005 Jul;314 (1) :410-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

A-425619

structure in first source

CAS Number581809-67-8
PubChem CID8068410
IUPAC Name1-isoquinolin-5-yl-3-[[4-(trifluoromethyl)phenyl]methyl]urea
Molecular FormulaC18H14F3N3O
Molecular Weight345.3
XLogP3.5
Topological Polar Surface Area54
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity449
SMILES
C1=CC2=C(C=CN=C2)C(=C1)NC(=O)NCC3=CC=C(C=C3)C(F)(F)F
InChI
InChI=1S/C18H14F3N3O/c19-18(20,21)14-6-4-12(5-7-14)10-23-17(25)24-16-3-1-2-13-11-22-9-8-15(13)16/h1-9,11H,10H2,(H2,23,24,25)
InChIKey
SJGVXVZUSQLLJB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of A-425619
CAS: 581809-67-8
CID: 8068410
Formula: C18H14F3N3O
MW: 345.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.3
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass345.10889656
Monoisotopic Mass345.10889656
Topological Polar Surface Area54 Ų
Heavy Atom Count25
Formal Charge0
Complexity449
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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