Products for Research Use Only
RegisterLogin

A-425619

CAT: 0804-HY-110292-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-110292-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
A-425619 is an orally active and selective transient receptor potential type V1 (TRPV1) antagonist. A-425619 blocks Capsaicin - and N-arachidonoyl-dopamine (NADA) -induced Ca2+ influx in dorsal root ganglia and trigeminal ganglia. A-425619 relieves pathophysiological pain associated with inflammation and tissue injury in rats. A-425619 can be used for the study of pain related to inflammation and tissue injury[1][2][3].
CAS Number
581809-67-8
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Calcium Channel; TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/a-425619.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)C(C=C1)=CC=C1CNC(NC2=CC=CC3=C2C=CN=C3)=O
Molecular Formula
C18H14F3N3O
Molecular Weight
345.32
Precautions
H315, H319, H320
References & Citations
[1]McDonald HA, et al. Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia. Eur J Pharmacol. 2008 Oct 31;596 (1-3) :62-9. |[2]El Kouhen R, et al. A-425619 [1-isoquinolin-5-yl-3- (4-trifluoromethyl-benzyl) -urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid. J Pharmacol Exp Ther. 2005 Jul;314 (1) :400-9. |[3]Honore P, et al. A-425619 [1-isoquinolin-5-yl-3- (4-trifluoromethyl-benzyl) -urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. J Pharmacol Exp Ther. 2005 Jul;314 (1) :410-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-13466-01MK-4256
HY-174458MD-4251
HY-R00938-01Hsa-miR-4259 mimic
HY-RI00938-01Hsa-miR-4259 inhibitor
HY-R00935-01Hsa-miR-4256 mimic
HY-R00938A-01Hsa-miR-4259 agomir
HY-R00935A-01Hsa-miR-4256 agomir
HY-RI00935A-01Hsa-miR-4256 antagomir
HY-RI00929-01Hsa-miR-4251 inhibitor
HY-RI00935-01Hsa-miR-4256 inhibitor

Alternative Products

CatalogName
T8562-01A 425619
BA7062-1A-425619
5781/50A 425619 50 mg
5781/10A 425619 10 mg

Popular Products