MK-4256

• Description:

  MK-4256 is a potent and selective SSTR3 antagonist with IC50s of 0.66 nM and 0.36 nM in human and mouse receptor binding assays, respectively.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Somatostatin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/MK-4256.html

• Purity:

  99.07

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  CN1N=CC ([C@@]2 (C3=NOC (C) =N3) N[C@@H] (C4=NC=C (C5=CC=C (F) C=C5) N4) CC6=C2NC7=C6C=CC=C7) =C1

• Molecular Formula:

  C27H23FN8O

• Molecular Weight:

  494.52

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]He S, et al. The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2012 May 7;3 (6) :484-9.|[2]He S, et al. Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists. ACS Med Chem Lett. 2014 Apr 21;5 (7) :748-53.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1104599-69-0