BIMU 8

• Description:

  BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bimu-8.html

• Purity:

  99.60

• Solubility:

  DMSO : 37.79 mg/mL (ultrasonic)

• Smiles:

  CN ([C@@H] (CC1) C2) [C@H]1C[C@@H]2NC (N3C4=C (C=CC=C4) N (C (C) C) C3=O) =O.[Cl-]

• Molecular Formula:

  C19H26ClN4O2-

• Molecular Weight:

  377.89

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]C Ghelardini, et al. Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. Life Sci. 1996;58 (25) :2297-309.|[2]Lucie P Pellissier, et al. Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol. 2009 Apr;75 (4) :982-90.|[3]H Pan , et al. 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol. 1994 Feb;266 (2 Pt 1) :G230-8.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Apolipoprotein D

• CAS Number:

  134296-40-5