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BIMU 8

CAT: 0804-HY-110094Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110094Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors[1][2].
CAS Number
134296-40-5
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bimu-8.html
Purity
99.60
Solubility
DMSO : 37.79 mg/mL (ultrasonic)
Smiles
CN([C@@H](CC1)C2)[C@H]1C[C@@H]2NC(N3C4=C(C=CC=C4)N(C(C)C)C3=O)=O.[Cl-]
Molecular Formula
C19H26ClN4O2-
Molecular Weight
377.89
Precautions
H315, H319, H335
References & Citations
[1]C Ghelardini, et al. Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. Life Sci. 1996;58 (25) :2297-309.|[2]Lucie P Pellissier, et al. Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol. 2009 Apr;75 (4) :982-90.|[3]H Pan , et al. 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol. 1994 Feb;266 (2 Pt 1) :G230-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Apolipoprotein D

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