Anticancer agent 124

• UNSPSC Description:

  Anticancer agent 124 is an orally active, highly selective and potent pan RAF inhibitor. Anticancer agent 124 inhibits MAPK signalling in BRAF V600E, NRAS and KRAS mutant tumor cells[1].

• Target Antigen:

  Raf

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-124.html

• Solubility:

  10 mM in DMSO|H2O : < 0.1 mg/mL

• Smiles:

  O=C1NC2=C(C(OC3=CC=C4C(CC(C5=NC=C(C6=CC=CC=C6Cl)N5)CO4)=C3)=CC=N2)CC1

• Molecular Weight:

  472.92

• References & Citations:

  [1]Helen Mason, et al. Abstract 5160: Development of REDX05358, a novel highly selective and potent pan RAF inhibitor and a potential therapeutic for BRAF and RAS mutant tumors. Cancer Res 1 July 2017; 77 (13_Supplement): 5160.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4