Anticancer agent 124

• Description :

  Anticancer agent 124 is an orally active, highly selective and potent pan RAF inhibitor. Anticancer agent 124 inhibits MAPK signalling in BRAF V600E, NRAS and KRAS mutant tumor cells[1].

• UNSPSC :

  12352005

• Target :

  Raf

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-124.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1NC2=C(C(OC3=CC=C4C(CC(C5=NC=C(C6=CC=CC=C6Cl)N5)CO4)=C3)=CC=N2)CC1

• Molecular Formula :

  C26H21ClN4O3

• Molecular Weight :

  472.92

• References & Citations :

  [1]Helen Mason, et al. Abstract 5160: Development of REDX05358, a novel highly selective and potent pan RAF inhibitor and a potential therapeutic for BRAF and RAS mutant tumors. Cancer Res 1 July 2017; 77 (13_Supplement) : 5160.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1884226-20-3]