L-AP3

CAT: 0804-HY-108546-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-108546-02Size:5 mg

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Description

L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively[1].

CAS Number

23052-80-4

Product Name Alternative

3-Phosphono-L-alanine

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-ap3.html

Purity

99.91

Solubility

10 mM in DMSO

Smiles

N[C@@H](CP(O)(O)=O)C(O)=O

Molecular Formula

C3H8NO5P

Molecular Weight

169.07

Precautions

H302, H312, H332

References & Citations

[1]J E Hawkinson, et al. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur J Pharmacol. 1996 Jun 27;307 (2) :219-25.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

3-Phosphono-L-alanine

(2R)-2-amino-3-phosphonopropanoic acid is a L-alpha-amino acid.

CAS Number	23052-80-4
PubChem CID	177120
IUPAC Name	(2R)-2-amino-3-phosphonopropanoic acid
Molecular Formula	C3H8NO5P
Molecular Weight	169.07
XLogP	-5.2
Topological Polar Surface Area	121
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Heavy Atom Count	10
Formal Charge	0
Complexity	174

SMILES

C([C@@H](C(=O)O)N)P(=O)(O)O

InChI

InChI=1S/C3H8NO5P/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1

InChIKey

LBTABPSJONFLPO-REOHCLBHSA-N

Chemical Structure

2D Structure

CAS: 23052-80-4

CID: 177120

Formula: C3H8NO5P

MW: 169.07

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	169.07
XLogP3	-5.2
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	169.01400935
Monoisotopic Mass	169.01400935
Topological Polar Surface Area	121 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	174
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
ALX-550-038-M005	L-AP3
MBS851360-01	AP3 Antibody
MBS3613562-01	DL-AP3
GTR18085399	Anti-AP3
AP-3	AP3 primer
NU-514	AP3 (Nic)
sc-391031	D-AP3

L-AP3

Chemical Information

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