L-AP3

• Description:

  L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively[1].

• Product Name Alternative:

  3-Phosphono-L-alanine

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H312, H332

• Target:

  MGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/l-ap3.html

• Purity:

  99.91

• Solubility:

  10 mM in DMSO

• Smiles:

  N[C@@H](CP(O)(O)=O)C(O)=O

• Molecular Formula:

  C3H8NO5P

• Molecular Weight:

  169.07

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]J E Hawkinson, et al. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur J Pharmacol. 1996 Jun 27;307 (2) :219-25.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [23052-80-4]