L-AP3

• Description :

  L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively[1].

• Product Name Alternative :

  3-Phosphono-L-alanine

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H312, H332

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/l-ap3.html

• Purity :

  99.91

• Solubility :

  10 mM in DMSO

• Smiles :

  N[C@@H](CP(O)(O)=O)C(O)=O

• Molecular Formula :

  C3H8NO5P

• Molecular Weight :

  169.07

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]J E Hawkinson, et al. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur J Pharmacol. 1996 Jun 27;307 (2) :219-25.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [23052-80-4]