4α-TPA

• Description:

  4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events[1].

• Product Name Alternative:

  α-TPA

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  NF-κB; PKC; SphK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; Immunology/Inflammation; NF-κB; TGF-beta/Smad

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/4α-tpa.html

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H]([C@H]2OC(CCCCCCCCCCCCC)=O)C)([C@@]4([H])[C@@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O

• Molecular Formula:

  C36H56O8

• Molecular Weight:

  616.83

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Chiu WT, et al. Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE (2) activation. Neurobiol Dis. 2010;37 (1) :118-129.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [63597-44-4]