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TPA Protein

CAT: 0247-OPPA00785-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0247-OPPA00785-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Aliases
TPA, T-PA
Gene ID
5327
Accession Number
NP_000921.1
Reactivity
Human
Target
Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine protease which converts plasminogen into plasmin, a fibrinolyticenzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysiswhich can result in thrombosisor embolism. Tissue Plasminogen Activator Human Recombinant produced in CHO cells is a single, glycosylated polypeptide chain containing 527 amino acids.
Type
Protein
Source
Chinese Hamster Ovarian Cells (CHO)
Purification
Purified by proprietary chromatographic techniques.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Bioactivity
Enzymatic Activity: //580,000 IU/mg.
Format
Lyophilized// Each mg of tPA contains 1.7 grams L-arginine, 0.5 g phosphoric acid and 4 mg tween 80 Physical Appearance:// Sterile filtered white freeze-dried powderPhysical Appearance:// Sterile filtered white freeze-dried powder
Reconstitution
2
Molecular Weight
59 kDa
Notes
Formerly GWB-2067B9
Protein Length
Recombinant
NCBI Gene Symbol
TPA
Protein Name
Tissue-type plasminogen activator
Gene Name URL
TPA

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