T-0156

CAT: 0804-HY-105349Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-105349Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM) . T-0156 inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM) . T-0156 enhances the nitric oxide (NO) /cGMP pathway[1].
CAS Number
[324572-93-2]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/t-0156.html
Solubility
10 mM in DMSO
Smiles
COC(C(N1CC2=CC=NC(C)=C2)=C(C3=CC(OC)=C(OC)C(OC)=C3)C4=CC=NC(OCC5=NC=CC=N5)=C4C1=O)=O.Cl
Molecular Formula
C31H30ClN5O7
Molecular Weight
620.05
References & Citations
[1]Hideki Mochida, et al. Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur J Pharmacol. 2002 Dec 5;456 (1-3) :91-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1; PDE2; PDE3; PDE4; PDE5; PDE6

Related Products

CatalogName
HY-145274EB-0156
HY-D0218-01Thioflavin T
HY-W015764-01T-1105
HY-N12788-01T-Cadinol
HY-120661T-1840383
HY-117938T-3861174
HY-125594T-1095A
HY-102045-01T-3764518
HY-105181T 588
HY-118490T-2000

Alternative Products

CatalogName
BUP03208-01T-0156
B5162-50T 0156 hydrochloride
MF-0037917-01T-0156 hydrochloride
532801T-0156 hydrochloride
MBS3602809-01AZD-0156
MBS5805845EB-0156
TRC-A216040-75MGAZD 0156
E11-124117Insulin (Clone 0156) Mouse mAb
ABL-TC0651T.T
042546T, NT (T, Brachyury protein, Protein T)

Popular Products