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T-0156 (free base)

CAT: 0804-HY-164685-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164685-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
T-0156 free base is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 free base specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM) . T-0156 free base inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM) . T-0156 free base enhances the nitric oxide (NO) /cGMP pathway[1].
CAS Number
324572-92-1
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/t-0156-free-base.html
Smiles
O=C(C1=C(C2=CC(OC)=C(OC)C(OC)=C2)C3=CC=NC(OCC4=NC=CC=N4)=C3C(N1CC5=CC(C)=NC=C5)=O)OC
Molecular Formula
C31H29N5O7
Molecular Weight
583.59
References & Citations
[1]Hideki Mochida, et al. Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur J Pharmacol. 2002 Dec 5;456 (1-3) :91-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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