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(Rac) -BIIB042

CAT: 0804-HY-103537Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-103537Size:1 Each
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Description
(Rac) -BIIB042 (Compound 10) is an modulator of γ-Secretase. (Rac) -BIIB042 reduces Amyloid-β 42 level with an EC50 value of 0.39 µM. (Rac) -BIIB042 can be used for the study of Alzheimer's disease[1].
CAS Number
1257395-14-4
UNSPSC
12352005
Target
Amyloid-β; γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rac-biib042.html
Solubility
10 mM in DMSO
Smiles
OC(C(C)C(C=C1)=CC(C2=CC=C(C(F)(F)F)C=C2)=C1C(N3CCC(C)CC3)C4=CC=C(F)C=C4)=O
Molecular Formula
C29H29F4NO2
Molecular Weight
499.54
References & Citations
[1]Peng H, et al. Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator. ACS Med Chem Lett. 2011 Aug 5;2 (10) :786-91.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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