(Rac)-Tezacaftor

• UNSPSC Description:

  (Rac)-Tezacaftor ((Rac)-VX-661) is a racemate of Tezacaftor (HY-15448). Tezacaftor is a F508del CFTR corrector. (Rac)-Tezacaftor can be used for the research of cystic fibrosis[1].

• Target Antigen:

  CFTR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/rac-tezacaftor.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=C(NC(C2(CC2)C3=CC4=C(OC(F)(F)O4)C=C3)=O)C=C(C=C5C(C)(C)CO)C(N5CC(O)CO)=C1

• Molecular Weight:

  520.50

• References & Citations:

  [1]Keating D, et al. VX-445-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379(17):1612-1620.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1226709-85-8