SB-221284

• Description :

  SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease[1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/sb-221284.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1CCC2=C1C=C(C(F)(F)F)C(SC)=C2)NC3=CC=CN=C3

• Molecular Formula :

  C16H14F3N3OS

• Molecular Weight :

  353.36

• References & Citations :

  [1]Hutson PH, et al. Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT (2C/2B) receptor antagonists: neurochemical and behavioural studies. Neuropharmacology. 2000;39 (12) :2318-2328.|[2]Bromidge SM, et al. Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1- (3-pyridylcarbamoyl) indolines. J Med Chem. 1998;41 (10) :1598-1612.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT2 Receptor; α-1 microglobulin

• CAS Number :

  [196965-14-7]