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GSK-5503A

CAT: 0804-HY-103071Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-103071Size:1 Each
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Description
GSK-5503A is a calcium-release activated calcium (CRAC) channel blocker. GSK-5503A effectively inhibits stromal interaction molecule 1 (STIM1) mediated Orai1 and Orai3 currents in vitro. GSK-5503A can be used for the research of asthma and allergic disorders[1].
CAS Number
1253186-46-7
UNSPSC
12352005
Target
CRAC Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk-5503a.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NN(CC2=CC=CC=C2OC3=CC=CC=C3)C=C1)C4=C(F)C=CC=C4F
Molecular Formula
C23H17F2N3O2
Molecular Weight
405.40
References & Citations
[1]Derler I, et al. The action of selective CRAC channel blockers is affected by the Orai pore geometry. Cell Calcium. 2013 Feb;53 (2) :139-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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