GSK-J2

• Description :

  GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

• CAS Number :

  [1394854-52-4]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Histone Demethylase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/GSK-J2.html

• Purity :

  99.75

• Solubility :

  DMSO : ≥ 42 mg/mL

• Smiles :

  O=C(O)CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1

• Molecular Formula :

  C22H23N5O2

• Molecular Weight :

  389.45

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514 (7520) :E1-2

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported