Iloperidone-13C, d3

• Description:

  Iloperidone-13C, d3 (HP 873-13C, d3) is 13C labeled Iloperidone. Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms[1][2].

• Product Name Alternative:

  HP 873-13C, d3

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Dopamine Receptor; Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling; Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(C)C1=CC=C(C(O[13C]([2H])([2H])[2H])=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(F)=C4

• Molecular Formula:

  C23 13CH24D3FN2O4

• Molecular Weight:

  430.49

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kongsamut, S., et al., Iloperidone binding to human and rat dopamine and 5-HT receptors. Eur J Pharmacol, 1996. 317 (2-3) : p. 417-23.|[3]Sainati, S.M., et al., Safety, tolerability, and effect of food on the pharmacokinetics of iloperidone (HP 873), a potential atypical antipsychotic. J Clin Pharmacol, 1995. 35 (7) : p. 713-20.|[4]Albers, L.J., A. Musenga, and M.A. Raggi, Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market? Expert Opin Investig Drugs, 2008. 17 (1) : p. 61-75.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported