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Prostaglandin D2-d9

CAT: 0804-HY-101988S1Size: 100 μg (276.61 μM x 1 mL in Methyl Acetate)Dry Ice: NoHazardous: No
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CAT#:0804-HY-101988S1Size:100 μg (276.61 μM x 1 mL in Methyl Acetate)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Prostaglandin D2-d9 is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].
CAS Number
2254642-52-7
Product Name Alternative
PGD2-d9
UNSPSC
12352211
Target
Endogenous Metabolite; Prostaglandin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Concentration
276.61 μM * 1 mL in Methyl acetate
Purity
99.0
Solubility
10 mM in DMSO|DMSO : 50mg/mL (ultrasonic; warming) |Ethanol : 75mg/mL (ultrasonic; warming)
Smiles
O[C@@H]1[C@@H]([C@H](C(C1)=O)/C=C/[C@H](CC([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])O)C/C=C\CCCC(O)=O
Molecular Formula
C20H23D9O5
Molecular Weight
361.52
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385 (2) :321-8.|[3]Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38 (4) :469-476.|[4]Kida T, et al. Prostaglandin D2 Attenuates NSC 125066-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11 (12) :e0167729.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
DP

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