Prostaglandin E2-d9

CAT: 0804-HY-101952S1Size: 50 μg (1.38 mM x 100 μL in Methyl Acetate)Dry Ice: NoHazardous: No
CAT#:0804-HY-101952S1Size:50 μg (1.38 mM x 100 μL in Methyl Acetate)
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Description
Prostaglandin E2-d9 is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].
CAS Number
[1356347-42-6]
Product Name Alternative
PGE2-d9; Dinoprostone-d9
UNSPSC
12352211
Hazard Statement
H302, H360
Target
Endogenous Metabolite; Isotope-Labeled Compounds; Prostaglandin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease; Endocrinology
Concentration
1.38 mM * 100 μL in Methyl acetate
Purity
99.5
Solubility
10 mM in DMSO
Smiles
OC(CCC/C=C\C[C@@H]1[C@H]([C@@H](CC1=O)O)/C=C/[C@@H](O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O
Molecular Formula
C20H23D9O5
Molecular Weight
361.52
Precautions
H302, H360
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Chouaib S, et al. The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes. J Immunol. 1984 Apr;132 (4) :1851-7.|[3]Fernandez-Repollet E, et al. In vivo effects of prostaglandin E2 and arachidonic acid on phagocytosis of fluorescent methacrylate microbeads by rat peritoneal macrophages. J Histochem Cytochem. 1982 May;30 (5) :466-70.|[4]Haylor J, et al. Renal vasodilator activity of prostaglandin E2 in the rat anaesthetized with pentobarbitone. Br J Pharmacol. 1982 May;76 (1) :131-7.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
EP

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