Tyrphostin 25

• Description :

  Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM[1][2][3].

• Product Name Alternative :

  AG82; Tyrphostin A 25; Tyrphostin AG 82; RG-50875

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H332

• Target :

  EGFR; GPR35

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/tyrphostin-25.html

• Purity :

  99.00

• Solubility :

  DMSO : 30 mg/mL (ultrasonic; warming)

• Smiles :

  N#C/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1

• Molecular Formula :

  C10H6N2O3

• Molecular Weight :

  202.17

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994 Nov;127 (3) :859-66. |[2]Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32 (10) :2344-52.|[3]Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011 Jun 23;585 (12) :1957-62.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [118409-58-8]