GNE-955

• Description :

  GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319

• Target :

  Pim

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/GNE-955.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=CN=CC(C2=CC3=C(C=NN3C4=CC=C(OC)C(N5CCC[C@H](N)C5)=N4)C=N2)=N1

• Molecular Formula :

  C22H24N8O

• Molecular Weight :

  416.48

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362+P364

• References & Citations :

  [1]Wang X, et al. Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J Med Chem. 2017 May 25;60 (10) :4458-4473.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PIM1; PIM2; PIM3

• CAS Number :

  [1527523-39-2]