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SCH 42495

CAT: 0804-HY-101682Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101682Size:1 Each
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Description
SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354[1].
CAS Number
136511-43-8
UNSPSC
12352005
Target
Neprilysin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Sch-42495.html
Solubility
10 mM in DMSO
Smiles
CSCC[C@@H](C(OCC)=O)NC([C@@H](CSC(C)=O)CC1=CC=CC=C1C)=O
Molecular Formula
C20H29NO4S2
Molecular Weight
411.58
References & Citations
[1]Watkins RW, et al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6 (5 Pt 1) :357-68.|[2]Thompson JS, et al. Effects of the neutral endopeptidase inhibitor, SCH 42495, on the cardiovascular remodelling secondary to chronic hypoxia in rats. Clin Sci (Lond) . 1994 Jul;87 (1) :109-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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