β3-AR agonist 1

CAT: 0804-HY-101514Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-101514Size:1 Each
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold) [1].
CAS Number
[1283125-73-4]
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/beta-3-ar-agonist-1.html
Solubility
10 mM in DMSO
Smiles
O=S(NC1=CC([C@@H](O)CNCCOC2=CC(NN=C3C)=C3C=C2)=CC=C1)(C4CCC4)=O
Molecular Formula
C22H28N4O4S
Molecular Weight
444.55
References & Citations
[1]Wada Y, et al. Discovery of Novel Indazole Derivatives as Orally Available β3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects. J Med Chem. 2017 Apr 27;60 (8) :3252-3265.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor

Popular Products