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RS-102221

CAT: 0804-HY-101365Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101365Size:1 Each
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Description
RS-102221 is a selective 5-HT2C receptor antagonist (Ki=10 nM) . RS-102221 shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 can promote the differentiation of new nerve cells. RS-102221 increases food-intake and weight-gain in rats[1][2].
CAS Number
185376-97-0
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rs-102221.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(C(F)(F)F)C=C1)(NC2=CC(C(CCCCN(CC3)CCC3(NC(N4)=O)C4=O)=O)=C(OC)C=C2OC)=O
Molecular Formula
C27H31F3N4O7S
Molecular Weight
612.62
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Bortolotto V, et al. Proneurogenic Effects of Trazodone in Murine and Human Neural Progenitor Cells. ACS Chem Neurosci. 2017 Sep 20;8 (9) :2027-2038. |[2]Bonhaus DW, et al. RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist. Neuropharmacology. 1997 Apr-May;36 (4-5) :621-9. |[3]Salzer I, et al. Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca (2+) -activated chloride channels. Neuropharmacology. 2016 Nov;110 (Pt A) :277-286. |[4]Conductier G, et al. 3,4-N-methlenedioxymethamphetamine-induced hypophagia is maintained in 5-HT1B receptor knockout mice, but suppressed by the 5-HT2C receptor antagonist RS102221. Neuropsychopharmacology. 2005 Jun;30 (6) :1056-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; α-1 microglobulin

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