(S, S) -D211

• Description:

  (S, S) -D211 is a stereoisomer of D211. (S, S) -D211 belongs to PBD dimer family with DNA damage activity. (S, S) -D211 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) [1].

• UNSPSC:

  12352005

• Target:

  ADC Payload; DNA/RNA Synthesis

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  O=C1N2[C@@](C=NC3=CC(OCCCOC4=C(C=C5C(N=C[C@@]6([H])N(CC7=CC=CC=C7C6)C5=O)=C4)OC)=C(OC)C=C31)([H])CC8=CC=CC=C8C2

• Molecular Formula:

  C39H36N4O6

• Molecular Weight:

  656.73

• References & Citations:

  [1]Smith SW, et al. Design and Synthesis of Isoquinolidinobenzodiazepine Dimers, a Novel Class of Antibody-Drug Conjugate Payload. ACS Med Chem Lett. 2017 Dec 6;9 (1) :56-60.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1971075-99-6]