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Trifluoperazine (dimaleate)

CAT: 0804-HY-B0532BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0532BSize:1 Each
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Description
Trifluoperazine dimaleate, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dimaleate is a potent α1-adrenergic receptor antagonist. Trifluoperazine dimaleate is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dimaleate is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dimaleate can be used for the research of schizophrenia. Trifluoperazine dimaleate acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].
CAS Number
605-75-4
UNSPSC
12352005
Target
Adrenergic Receptor; Autophagy; CaMK; Dopamine Receptor; Influenza Virus; P-glycoprotein
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trifluoperazine-dimaleate.html
Solubility
10 mM in DMSO
Smiles
O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.FC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F
Molecular Formula
C29H32F3N3O8S
Molecular Weight
639.64
References & Citations
[1]Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23 (1) :67-70.|[2]Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129 (6) :2500-2513. Published 2019 Mar 28.|[3]Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004 (1) :CD003545.|[4]Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54 (1) :20-22.|[5]Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15 (2) :149-160.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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