Trifluoperazine

CAT: 0804-HY-B0532-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0532-01Size:1 mg
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Description
Trifluoperazine, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine is a potent α1-adrenergic receptor antagonist. Trifluoperazine is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine can be used for the research of schizophrenia. Trifluoperazine acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].
CAS Number
[117-89-5]
UNSPSC
12352005
Target
Adrenergic Receptor; Autophagy; CaMK; Dopamine Receptor; Influenza Virus; P-glycoprotein
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trifluoperazine.html
Purity
99.87
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F
Molecular Formula
C21H24F3N3S
Molecular Weight
407.50
References & Citations
[1]Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129 (6) :2500-2513. Published 2019 Mar 28.|[2]Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004 (1) :CD003545.|[3]Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54 (1) :20-22.|[4]Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23 (1) :67-70.|[5]Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15 (2) :149-160.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Chem Biol Interact. 2024 Apr 1:392:110904.|Food Biosci. 2024 Feb, 57, 103513.|bioRxiv. 2024 June 12.|BMC Med Genomics. 2024 Jan 2;17 (1) :12.|CNS Neurosci Ther. 2023 Mar;29 (3) :831-841.|Free Radic Biol Med. 2025 Feb 1:227:64-79.|J Transl Med. 2024 Aug 1;22 (1) :715.|Mol Med Rep. 2021 May;23 (5) :319.|Sci Rep. 2025 May 8;15 (1) :16053.

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