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20-5,14-HEDE

CAT: 0804-HY-160099-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160099-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
20-5,14-HEDE (WIT003) is an analog of 20-HETE. 20-5,14-HEDE activates PI3K/Akt signaling pathway, thereby exhibiting anti-apoptotic and cell survival promoting effects. 20-5,14-HEDE is the agonist for 20-HETE that increases intracellular Ca2+ concentrations, thereby enhancing vasoconstriction[1][2].
CAS Number
240427-86-5
Product Name Alternative
WIT003
UNSPSC
12352211
Target
Akt; Apoptosis; Caspase; DNA/RNA Synthesis; PI3K; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/20-5-14-hede.html
Purity
98.34
Solubility
DMSO : ≥ 150 mg/mL
Smiles
OCCCCC/C=C\CCCCCCC/C=C\CCCC(O)=O
Molecular Formula
C20H36O3
Molecular Weight
324.50
References & Citations
[1]Dhanasekaran, et al. "20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells." American Journal of Physiology-Heart and Circulatory Physiology 296.3 (2009) : H777-H786.|[2]Yu M, et al., Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. Eur J Pharmacol. 2004 Feb 23;486 (3) :297-306.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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