(±) 15-HEDE

• Description:

  (±) 15-HEDE is a racemic mixture of the monohydroxy fatty acids 15 (R) -HEDE and 15 (S) -HEDE. 15-HEDE is formed from eicosadienoic acid in macrophages. It inhibits 5-lipoxygenase (5-LO; IC50=35 μM) .

• UNSPSC:

  12352211

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Lipoxygenase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/racemic-15-hede.html

• Smiles:

  CCCCCC(O)/C=C/C=C\CCCCCCCCCC(O)=O

• Molecular Formula:

  C20H36O3

• Molecular Weight:

  324.50

• Precautions:

  P261-P280-P302+P352

• References & Citations:

  [1]Haviv, et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J. Med. Chem. 30 (2), 254-263 (1987) .

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [77159-57-0]