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CD74 Antibody / CLIP

CAT: 0800-V5108-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V5108-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
It recognizes a protein of ~35kDa, identified as CD74 (Workshop IV) . CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+) .
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P04233
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human CD74 protein was used as the immunogen for the CD74 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RCLIP/8679
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the CD74 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD74 antibody is available for research use only.
Storage Conditions
Aliquot the CD74 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CD74 antibody should be determined by the researcher.
Location
Cell surface, Paranuclear globular
Image Legend
IHC staining of FFPE human spleen tissue with CD74 antibody (clone rCLIP/8679) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P04233

HLA class II histocompatibility antigen gamma chain

HG2A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04233
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD74
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K7R1, B4DNE8, D3DQG3, D3DQG4, Q14597, Q29832, Q5U0J8, Q8SNA0, Q8WLP6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Coding sequence diversity

Alternative initiationAlternative splicing

Cellular component

Cell membraneEndoplasmic reticulumEndosomeGolgi apparatusLysosomeMembraneSecreted

Molecular function

Chaperone

PTM

Disulfide bondGlycoproteinPhosphoproteinProteoglycan

Domain

Signal-anchorTransmembraneTransmembrane helix
Product Datasheet
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