CLIP Antibody / CD74

CAT: 0800-V3180IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
CAT#:0800-V3180IHC-7MLSize:7 mL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes proteins of 33, 35 and 41kDa, which are identified as various isoforms of CD74/CLIP. Its epitope is localized in the extracellular domain of CD74. CD74/CLIP is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74/CLIP is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. It is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74/CLIP stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas and has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+) .
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P04233
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the CLIP antibody. Its epitope is localized in the extracellular domain of CLIP/CD74.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CLIP/813
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the CLIP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CLIP antibody is available for research use only.
Storage Conditions
Store the CLIP antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cell surface and paranuclear globular
Image Legend
IHC analysis of formalin/paraffin human tonsil with CLIP antibody (clone CLIP/813) .

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NBP3-23650-20ugRabbit Monoclonal CD74 Antibody (CLIP/8680R)
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NBP3-08927FRabbit Monoclonal CD74 Antibody (CLIP/3127R) [FITC]
NBP3-08927PCPRabbit Monoclonal CD74 Antibody (CLIP/3127R) [PerCP]
NBP3-11486PCPMouse Monoclonal CD74 Antibody (CLIP/1133) [PerCP]
NBP3-11568APCMouse Monoclonal CD74 Antibody (CLIP/813) [Allophycocyanin]
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