CLIP Antibody / CD74

CAT: 0800-V3180-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V3180-100UGSize:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Recognizes proteins of 33, 35 and 41kDa, which are identified as various isoforms of CD74/CLIP. Its epitope is localized in the extracellular domain of CD74. CD74/CLIP is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74/CLIP is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. It is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74/CLIP stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas and has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+) .
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells (methanol-fixed), Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Western blot: 1-2 µg/mL
UniProt
P04233
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the CLIP antibody. Its epitope is localized in the extracellular domain of CLIP/CD74.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CLIP/813
Applications
FACS, IF, IHC-P, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CLIP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CLIP antibody is available for research use only.
Storage Conditions
Store the CLIP antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface and paranuclear globular
Image Legend
Western blot testing of human Raji cell lysate with CLIP antibody (clone CLIP/813) . Expected molecular weight: 33-43 kDa.

Related Products

CatalogName
V5108-100UGCD74 Antibody / CLIP
V5108SAF-100UGCD74 Antibody / CLIP
V5110-100UGCD74 Antibody / CLIP
V5105SAF-100UGCD74 Antibody / CLIP
V5829-100UGCD74 Antibody / CLIP
V5829-20UGCD74 Antibody / CLIP
V5104SAF-100UGCD74 Antibody / CLIP
V5102-100UGCD74 Antibody / CLIP
V5103-20UGCD74 Antibody / CLIP
V5829SAF-100UGCD74 Antibody / CLIP

Alternative Products

CatalogName
NBP3-07225-100ugRabbit Monoclonal CD74 Antibody (CLIP/3127R)
NBP3-23650-20ugRabbit Monoclonal CD74 Antibody (CLIP/8680R)
NBP2-44990-0.1mgMouse Monoclonal CD74 Antibody (CLIP/813)
NBP3-11486Mouse Monoclonal CD74 Antibody (CLIP/1133)
NBP3-08927BRabbit Monoclonal CD74 Antibody (CLIP/3127R) [Biotin]
NBP3-08927FRabbit Monoclonal CD74 Antibody (CLIP/3127R) [FITC]
NBP3-08927PCPRabbit Monoclonal CD74 Antibody (CLIP/3127R) [PerCP]
NBP3-11486PCPMouse Monoclonal CD74 Antibody (CLIP/1133) [PerCP]
NBP3-11486APCMouse Monoclonal CD74 Antibody (CLIP/1133) [Allophycocyanin]
NBP3-11568BMouse Monoclonal CD74 Antibody (CLIP/813) [Biotin]

Popular Products