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Prostate Specific Antigen Antibody / PSA

CAT: 0800-V4646SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4646SAF-100UGSize:100 µg
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Description
Recognizes a single protein of 33-34kDa, identified as the prostate specific antigen (PSA) . This mAb is highly specific to PSA and stains prostatic secretory and ductal epithelium in both normal and neoplastic tissues. PSA is a chymotrypsin-like serine protease (kallikrein family) exclusively produced by the prostate epithelium, and abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT) . A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign prostate hyperplasia. This mAb makes an excellent pair with mAb 1A7G6B6 for PSA tests.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P07288
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 150-250) from the human protein was used as the immunogen for the Prostate Specific Antigen antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RKLK3/6947
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the Prostate Specific Antigen antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Prostate Specific Antigen antibody is available for research use only.
Storage Conditions
Aliquot the Prostate Specific Antigen antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Prostate Specific Antigen antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
IHC staining of FFPE human prostate carcinoma tissue with Prostate Specific Antigen antibody (clone rKLK3/6947) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P07288

Prostate-specific antigen

KLK3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07288
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KLK3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PSA
EC number
3.4.21.77
Processing
Precursor
Secondary accessions
C9JXH3, G3V0H4, G3XAE3, Q15096, Q16272, Q86TG8, Q8IXI4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

Domain

Signal

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