TIMP2 Antibody

• Description :

  It recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2) . It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A) . It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B) . TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

• Specifications :

  Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

• UniProt :

  P16035

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  A recombinant fragment of human TIMP2 protein was used as the immunogen for the TIMP2 antibody.

• Clonality :

  Recombinant Monoclonal

• Isotype :

  IgG κ

• Clone :

  TIMP2/8193R

• Type :

  Recombinant

• Applications :

  IHC-P

• Purity :

  Protein A/G affinity

• Format :

  Purified

• Buffer :

  1 mg/ml in 1X PBS; BSA free, sodium azide free

• Reconstitution :

  Aliquot the TIMP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations :

  This TIMP2 antibody is available for research use only.

• Storage Conditions :

  Aliquot the TIMP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation :

  1 mg/mL in 1X PBS; BSA free, sodium azide free

• Applications Notes :

  Optimal dilution of the TIMP2 antibody should be determined by the researcher.

• CAS Number :

  9000-83-3

• Location :

  Cytoplasm, Cell surface, Secreted

• Image Legend :

  IHC staining of FFPE human bladder carcinoma tissue with TIMP2 antibody (clone TIMP2/8193R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.