TIMP2 Antibody

CAT: 0800-V4548SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V4548SAF-100UGSize:100 µg
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Description
It recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2) . It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A) . It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B) . TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P16035
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant fragment of human TIMP2 protein was used as the immunogen for the TIMP2 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
TIMP2/8193R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the TIMP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TIMP2 antibody is available for research use only.
Storage Conditions
Aliquot the TIMP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the TIMP2 antibody should be determined by the researcher.
Location
Cytoplasm, Cell surface, Secreted
Image Legend
IHC staining of FFPE human bladder carcinoma tissue with TIMP2 antibody (clone TIMP2/8193R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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